I made a nice frame bag a few weeks ago for my Salsa Fargo, using Dimension Polyant VX21 which I thought felt like it would have impressive durability.
I got the chance to try the bag out on a local charity moutain bike ride a couple of weeks ago, and it performed perfectly, holding all the stuff I would normally have in my backback.
Anyway, once I'd removed the mud I found that after only 22 miles I'd worn two small holes in the fabric. One where it touched the bottle cage and one where it touched a bottle cage bolt on the seat tube.
I've patched them using some shoe goo glue and a couple of bits of innertube, but I thought if anyone has made anything similar for a big ride but hasn't yet tested it they might want to do so before they find themselves with stuff falling out of holes! Any obvious wear points definately need reinforcing.
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