I have two 29er bikes, both 2 X 10. One set up with Hammerschmidt with 22 tooth chainring. Cassette is 12X36.
The other bike is similar 2X10 but with 22 and 36 up front with 12X36 out back with Wolf Tooth 42 big ring on the cassette also.
I do a lot of climbing for the joy of the downhill on loop rides or out and back. The second bike with the Wolf Tooth 42 works great on the climbs. I will probably put a 42 tooth on the first bike too as I like it so much. The big ring works and shifts great. The Hammerschmidt rig is more downhill oriented as it has a Dorado Fork.